US-301 Accident Today: 3 Injured in Multi-Vehicle Crash in Brandywine, Maryland

A serious US-301 accident in Brandywine, Maryland, left three people injured Tuesday morning, August 25, 2026, after a vehicle reportedly fleeing deputies was involved in a multi-vehicle crash near the Prince George’s County line.

The collision happened on the 16700 block of Crain Highway (US-301), just before MD-5, prompting a major emergency response and the closure of all southbound lanes.

Three People Injured in US-301 Crash

Emergency crews responded to the scene after the multi-vehicle collision was reported at approximately 10:30 a.m.

Three people were trapped or otherwise required significant assistance following the crash and were extricated by emergency personnel.

Two of the injured people were transported by medical helicopter in critical condition, while a third person was taken to a hospital with serious injuries that were reported as not life-threatening.

The severity of the injuries prompted a substantial emergency response along the busy Crain Highway corridor.

Police Chase Connected to Brandywine Collision

Preliminary reports indicate the crash occurred after a vehicle was fleeing deputies.

Authorities are investigating the circumstances surrounding the pursuit and the events that led to the multi-vehicle collision.

The exact sequence of events remains under investigation, and authorities have not indicated that all circumstances surrounding the crash have been established.

Because the investigation is ongoing, additional information about the vehicle involved, the drivers and the events immediately preceding the collision may be released later.

US-301 Southbound Closed After Crash

The accident caused major disruption along US-301 near MD-5, with all southbound travel lanes blocked during the emergency response.

By late morning, officials were warning motorists approaching the area to expect significant delays and to follow directions from police and emergency personnel.

The closure affected traffic traveling through Brandywine and toward the Charles County area, creating additional congestion during the morning commute.

Motorists were advised to allow additional travel time and avoid the affected section of Crain Highway when possible.

Two Patients Transported by Medevac

The condition of the two people flown by helicopter underscores the seriousness of the crash.

Both were reported to be in critical condition following the collision. Another injured person was transported by ground ambulance with serious but non-life-threatening injuries.

No fatalities had been confirmed in the available reporting at the time of publication.

Authorities continue to investigate the circumstances of the crash, including the reported police pursuit and the actions of the vehicles involved.

Investigation Underway

The Maryland State Police are investigating the crash.

Investigators will work to establish how the pursuit unfolded, how the vehicles collided and what factors contributed to the severity of the accident.

As with any active crash investigation, early details may change as authorities gather additional evidence, review the scene and speak with witnesses.

The identities of those injured have not been publicly released in the information currently available.

For the injured individuals and their families, the immediate priority remains medical treatment and recovery following a violent collision that disrupted traffic along one of Prince George’s County’s major highways.

The US-301 accident remains under investigation, and further details may be released as authorities continue their inquiry.

Disclaimer: This article is based on preliminary information available about the August 25, 2026, crash on US-301 in Brandywine, Maryland. The investigation remains ongoing, and details concerning the circumstances, injuries or responsibility may change as authorities release additional information.